Udinese earned a famous 3-2 win over Liverpool at Anfield in UEFA Europa League Group A, despite falling behind to an early effort from Jonjo Shelvey.
Antonio Di Natale equalised early in the second half and a Sebastian Coates own goal and a quick third from Giovani Pasquale turned the game on its head. A late strike from Luis Suarez was too late for Liverpool.
Philippe Coutinho's 10th minute strike set Inter Milan on its way to its first win in Group H with a 3-1 success against Neftchi in Azerbaijan.
Inter, which had been held at home in its opening group game by Rubin Kazan, built on its lead with further strikes from Joel Obi and Marko Livaja before half-time. Nicolas Canales scored a 53rd minute consolation for the host side.
However, Rubin Kazan kept pace with the Italian giant with a 2-0 home win over Partizan Belgrade. Gokdeniz Karadeniz opened the scoring on the stroke of half-time and Alexander Ryazantsev added a second just after the break.
Reigning champion Atletico Madrid needed an injury time winner from Cristian Rodriguez to extend its run of wins to eight with a 1-0 triumph over Viktoria Plzen in Spain.
Also in Group B, Omer Damari struck an injury time equaliser for Hapoel Tel Aviv in a 1-1 draw at Portuguese side Academica, which led through a Salim Cisse effort.
Newcastle claimed a superb 3-0 win over Bordeaux in Group D with goals from Shola Amoebi, Papiss Cisse and an own goal from Henrique, while Club Brugge beat Maritimo 2-0 with goals from Carlos Bacca and Bjorn Vleminckx.
Hungarian side Videoton pulled off an upset in Group G as it strolled to a 3-0 home win over Sporting Lisbon.
The Belgian outfit had looked well on its way to another win in the other Group G game as it led Basel 2-0 in
But the host hit back to claim a point in a 2-2 draw thanks to a second half double from
Lazio nudged to its first win in Group J - Ederson hitting the only goal of the game in the 62nd minute against Maribor at the Stadio Olimpico. The visiting side had
Also in Group J, Tottenham was denied its first win by a late Toche equaliser for Panathinaikos in
In Group I, Gueida Fofana scored twice, including an injury-time winner, as Lyon earned its second straight win with a thrilling 4-3 triumph over Hapoel Kiryat Shmona in
Shimon Abuhatzira put the home side in front after just seven minutes before Fofana,
Hapoel clawed back level through
Last year's runner-up Athletic Bilbao slumped to a 3-1 defeat at Sparta Prague.
In Group K,
Hannover shrugged off the ninth minute dismissal of Turkish defender Karim Haggui to beat Spanish side Levante 2-1 in
Michel had put Levante in front from the spot after Haggui's red card, but
In the same group, two Nikola Durdic goals put Helsingborg 2-0 up against FC Twente but the Dutch side hit back to claim a 2-2 draw with goals from
In an early kick-off in Group A, veteran striker
Napoli's excellent start to the new season ran aground in Eindhoven where it was beaten 3-0 by PSV in Group F.
Walter Mazzarri's men went into the game unbeaten in seven but were behind after seven minutes from a Jeremain Lens strike, and Dries Mertens and Marcelo added further goals for the Dutch side.
Dnipro, which had beaten PSV in its opening game, claimed its second straight win as it came from behind twice to beat AIK 3-2 in Sweden.
Goals from Helgi Danielsson and Henok Goitom for the host were cancelled out by efforts from Nikola Kalinic and Vitaly Mandzyk before Evhen Seleznyov struck to seal the points seven minutes from time.
Ligue 1 leader Marseille returned to form in emphatic fashion after the weekend's humiliating defeat to Valenciennes as it beat Cypriot side AEL 5-1 in Group C.
Edwin Ouon put the visitor in front but goals from Rod Fanni, Michel Mendes, Andre Gignac and two for Loic Remy saw Marseille home.
There were six more goals in the other Group C tie as Fenerbahce won 4-2 at Borussia Monchengladbach.
Luuk De Jong put the host side in front but Cristian Baroni hit two and further goals were added by Raul Meireles and Dirk Kuyt, with Igor De Camargo grabbing the Germans' second.
A late own goal from Ragnar Sigurdsson gave Steaua Bucharest a 1-0 win over FC Copenhagen in Group E, while Jo-Inge Berget and Daniel Chima scored in Molde's 2-0 home win over Stuttgart.