Udinese, Torino and Carpi all reached the Coppa Italia fourth round after accounting for lower-league opposition.
Udinese defeated Lega Pro leader Novara 3-1 at home, Torino conceded the opener against Serie B's Pescara only to triumph 4-1, while Serie A debutant Carpi won 2-0 over Livorno after extra-time.
At the Stadio Communale Friuli, Udinese led 2-0 at half-time thanks to a 40-yard stunner from Guilherme and Cyril Thereau's tap-in two minutes apart.
The host's goalkeeper Orestis Karnezis gave Novara some hope in the 74th minute when he fumbled Daniele Buzzegoli's free-kick into the net but Edenilson saved his team-mate's blushes with a header five minutes later to wrap up Udinese's victory and send it into the fourth round.
In Turin, an own goal from Salvador Ichazo gave Pescara the lead in the 17th minute but Torino was ahead at the break after goals to Daniele Baselli and Afriyie Acquah.
Maximiliano Lopez and Josef Martinez added goals after the interval for Torino.
Carpi found it more difficult to dismiss former Serie B rival Livorno, with Ryder Matos's brace in extra-time seeing the Modena province club advance.