Inter Milan progressed to the quarter-finals of the Coppa Italia with a comfortable 3-0 victory over Cagliari at San Siro but Serie A side Genoa was sent packing by Lega Pro side Alessandria in a stunning boilover.
Alessandria pulled off a shock 2-1 extra-time win at Genoa to book their place in the last eight.
The Piedmont club became the first side from Italian's third tier to reach the last eight of the knockout cup competition for 32 years.
Alessandria, who had already sent Palermo out in the earlier rounds, took the lead at the start of the second half through Manuel Marras.
The Lega Pro side were forced to play out the closing stages with only 10 men following injury to Gianni Manfrin when all the substitutes had been used, and the Serie A side took advantage to conjure a stoppage-time equaliser through Leonardo Pavoletti.
However, the home side were not to be denied a famous victory as with 114 minutes on the clock, Riccardo Bocalon rolled in a dramatic winner.
Alessandria will face the winner of the tie between Roma and Spezia.
Serie A leaders Inter Milan, who were beaten 4-1 by Cagliari in Milan last season, secured safe passage to the next stage thanks to a first-half goal from Rodrigo Palacio and efforts from Marcelo Brozovic and Ivan Perisic in the second period.
It was not an easy night for Roberto Mancini's team against a side they had beaten just once in their previous eight meetings, and the Sardinians - who sit second in Serie B - pushed hard for a route back into the game after the interval and almost found an equaliser when Fabio Pisacane's header struck a post just after half-time.
Inter remained resolute, though, scoring twice in the final half-hour to book a last-eight tie with Napoli or Verona.