Luis Suarez has tested positive for coronavirus and is set to miss Atletico Madrid's La Liga clash with his former club Barcelona.
The 33-year-old will also sit out Uruguay's World Cup qualifier with Brazil on Wednesday (AEDT) after contracting COVID-19 while away with his national side.
Uruguay confirmed in a statement on Tuesday that Suarez and teammate Rodrigo Munoz, as well as backroom staff member Matias Faral, are all following coronavirus protocols.
The news comes five days before Suarez was set to take on Barcelona, the club he left for a nominal fee in September after six years at Camp Nou.
He has played nine times for Atletico since joining and has five goals in six La Liga outings. Only Real Sociedad's Mikel Oyarzabal has scored more, having played a further three games.
Suarez's six league goals have come from 22 shots, eight of which were on target, both of which are the most of any Atletico player this season.
Speaking to Marca this week, Suarez reiterated his disappointment at being forced out of Barcelona during the most recent transfer window.
"I was sad and hurt by the way I left – I already said it," he admitted. "But when they close a door, five more open to you where they value my work, professionalism and trajectory. I feel proud.
"Where they did not want me, there was another that wanted me. I found happiness and I'm enjoying this moment now."