Luis Suarez went off injured in the first half of Barcelona's opening LaLiga match of the season against Athletic Bilbao.
The striker appeared to hurt his calf muscle shortly before taking a shot that hit the post just after the half-hour mark at San Mames.
Uruguay international Suarez was given treatment but had to be withdrawn, being replaced by Rafinha.
It is the first time he has been substituted in the first half of a LaLiga game since he joined Barca from Liverpool in 2014.
Lionel Messi was missing from the match due to a calf injury suffered shortly before Barca travelled to the United States for two friendly matches against Napoli last week.
Philippe Coutinho was left out of the squad, with Barca confirming he is in talks with Bayern Munich over a loan move to the Bundesliga champions.
Ernesto Valverde's return to San Mames was goalless at half-time, with Rafinha having also been denied by the woodwork after replacing Suarez.