Antigua and Barbuda was stunned by St Lucia in CONCACAF World Cup qualifying, while Patrick Kluivert's Curacao was held.
The third-highest ranked country involved in the second round of qualifying for Russia 2018, Antigua and Barbuda suffered a setback as it lost the first leg of its tie 3-1 to St Lucia in North Sound.
The host at Sir Vivian Richards Stadium got off to the perfect start when Tevaughn Harriette struck in the 21st minute, but it was all downhill thereafter.
St Lucia equalised five minutes later through Tremain Paul and it led just past the hour-mark when David Henry was on target.
Substitute Troy Greenidge added a third in injury-time to give St Lucia a healthy buffer ahead of the second leg at the same venue.
Antigua and Barbuda, ranked 104th in the FIFA standings, is among the best of the 20 teams involved in the second round, ranked lower than only El Salvador (89th) and Guatemala (93rd).
Former Netherlands assistant Kluivert could not inspire Curacao to victory in Willemstad, as it was held 0-0 by Cuba.
Forward Gianluca Maria was sent off late for Curacao, ruling him out of the return leg in Havana.
Barbados is on track to progress after a 2-0 win over Aruba.
Mario Harte and Emmerson Boyce scored for Barbados in Oranjestad, although it finished with 10 men after Akeene Brown was dismissed.
Brown will miss the second leg at the Usain Bolt Sports Complex in Barbados.