The big guns may not have been in Coppa Italia action but Spezia and Virtus Entella gave fans drama in their respective ties.
Lecce, which was in Serie A as recently as 2012, looked to have forced extra-time in its clash at Spezia, but the third-tier side was unable to hold on.
Spezia edged the encounter in general play, but its fans were made to wait as it desperately sought a late goal to secure progression.
Eventually the winner did arrive as defender Filippo De Col grabbed the all-important goal to earn a 1-0 victory for Nenad Bjelica's men.
Benevento twice found itself a goal behind to host Virtus Entella in Chiavari, but the third-tier side did manage to avoid a regulation-time defeat.
The visitor was staring cup elimination in the face, only for Alessandro Marotta to net in the third minute of stoppage-time, but it eventually lost 7-6 on penalties.
There was to be no such drama for Cittadella, which defeated Pontedera 2-1 at Stadio Pier Cesare Tombolato.
Pontedera's Saverio Madrigali cancelled out Federico Gerardi's opener just before the break, but Cittadella's Alessandro Sgrigna scored the decisive goal 10 minutes into the second period.
Modena edged Monza 3-2 on penalties, after normal and extra time finished 0-0.