Southampton and Borussia Dortmund contest the second legs of their UEFA Europa League ties on Friday morning (AEST) having been given thorough tests by Midtjylland and Odd last week.
Thomas Tuchel's Dortmund found itself 3-0 down in Norway after 22 minutes before battling back to ensure a slender one-goal lead going into this week's second leg.
Ronald Koeman's Southampton needed a second-half Jay Rodriguez penalty to rescue a 1-1 draw with Midtjylland at St Mary's with the Premier League side having begun the season sluggishly, perhaps due to its European commitments.
Captain Jose Fonte told the club's official website after last weekend's goalless draw with Watford: "It’s a disappointing result but at the end of the day we need to take the positives.
"We take a clean sheet and move on to Thursday and we need to qualify for the group stages.
"We just need to believe in ourselves and trust in our team-mates because we have a great team and a great squad."
Ajax and Fenerbahce both enjoy one-goal advantages going into their second legs with Jablonec and Atromitos respectively, although Supercopa de Espana winner Athletic Bilbao returns to San Mames trailing Zilina 3-2.
Ernesto Valverde's side threw away a two-goal lead in Slovakia while Eredivisie side AZ did the same against Astra in Romania.
Five-goal hauls for Krasnodar and PAOK put them in control of ties against HJK and Brondby respectively while Viktoria Plzen, Lech Poznan and Rosenborg take 3-0 leads into their clashes with Vojvodina, Videton and Steaua Bucharest.
Bordeaux makes the long trip to Almaty with a 1-0 lead in tow against Kairat, fellow Ligue 1 outfit St Etienne remains level at one apiece with Milsami and Red Bull Salzburg will hope home advantage can see it overturn a 2-0 deficit against Dinamo Minsk.
Standard Liege also returns home trailing 2-0 in its tie with Molde while Rubin Kazan versus Rabotnicki and Panathanaikos's tie with Qabala remain all square at 1-1 and 0-0 respectively.
Sparta Prague enjoys a healthy 3-1 lead over Thun thanks to Borek Dockal's brace while elsewhere Slovan Liberec, Legia Warsaw, Qarabag and Belenenses hold slender 1-0 advantages ahead of second legs against Hajduk Split, Zorya, Young Boys and Rheindorf Altach.