Lazio eased into the last 16 of the Coppa Italia courtesy of a 3-0 win over Varese at the Stadio Olimpico.
An own goal from on-loan AC Milan defender Stefan Simic gave the Rome club the lead in the 24th minute before Filip Djordjevic doubled the home advantage just two minutes later.
Felipe Anderson's long-range pot shot deflected in 10 minutes from time put the result beyond doubt for the 2013 winner.
Stefano Pioli's side faces an away trip to Torino in the last 16.
In a closely-fought game at the Mapei Stadium, host Sassuolo edged past Serie B opponent Pescara courtesy of a 1-0 scoreline.
Antonio Floro Flores scored the only goal of the match for the Serie A side 10 minutes into the second half.
Sassuolo next faces a tough fifth-round trip to San Siro to take on Milan.
Verona also advanced to the last 16 as a Javier Saviola penalty gave it victory over 10-man Perugia.
Saviola made no mistake from the spot in the 17th minute after he had been fouled in the box by Marco Rossi.
Perugia's task was made much harder in the 53rd minute when Guillermo Giacomazzi received a second yellow card, leaving the Serie B side to battle on, ultimately in vain, for the remainder of the second half.
Verona travels to face Serie A's dominant side Juventus in the fifth round.