Four-time winner Sheffield United eased into the third round of the FA Cup with a 3-0 win over Plymouth Argyle.
Nigel Clough's side, which reached the semi-finals last season, sealed progression as a pair of Jose Baxter penalties put it 2-0 to the good after 62 minutes, with Mark McNulty putting the gloss on the victory in the last minute.
Preston North End, a two-time winner itself, secured a 1-0 success against Shrewsbury Town, defender Paul Huntington settling the tie in the Lancashire club's favour with a 19th-minute effort.
Meanwhile, MK Dons tumbled out of the competition as it was beaten 1-0 at home by Chesterfield, and Oldham Athletic lost to Doncaster Rovers by the same scoreline courtesy of Genseric Kusunga's 86th-minute own goal.
Kwesi Appiah scored in the second minute of injury-time to earn a replay for Cambridge United as Richard Money's side drew 2-2 with Mansfield Town in Adam Murray's first game as permanent manager.
There was no fairytale for seventh-tier Maidstone United, which lost 3-1 at Conference Premier side Wrexham.
Manny Smith's first-half goal set the host on its way, with Maidstone's hopes of a comeback dashed by Aaron Simpson's foul on Wes York in the box.
Andy Bishop converted the subsequent penalty in the 57th minute and, although Alex Flisher pulled a goal back for the visitor just past the hour mark, it could not complete the comeback as Bishop made the game safe for the Welsh side with his second.
League Two Accrington Stanley held League One Yeovil Town to a 1-1 draw, while Daniel Nardiello netted in the 91st minute to ensure a 1-1 draw for Bury at home to Luton Town.
Elsewhere, Oxford United drew 2-2 with Tranmere Rovers.