Ajaccio was dumped out of the Coupe de France on penalties by third-tier Rouen.
The Ligue 1 struggler needed an 88th-minute equaliser from Wilfried Zahibo simply to force extra-time, Rouen having led after Zahir Zerdab won and hammered home a 63rd-minute free-kick.
But Rouen won 3-2 on penalties,
Evian almost suffered the same fate, only edging past fourth-tier Amiens on spot-kicks after leaving it even later in normal time.
Reims suffered a 1-0 defeat to fourth-tier Plabennec, Steven Coat with the only goal in the 27th minute.
Lille held off a second-half fightback to beat Nimes 3-2.
A strong Lille side led 3-0 after 52 minutes thanks to goals from
There were 1-0 wins on the road for three other top-flight teams, Sochaux, Toulouse and Troyes.
Nancy, bottom of Ligue 1, took the opportunity of some light relief in the cup with its first win since the opening day of the season.
Benjamin Moukandjo eliminated any threat of an upset against fifth-tier Dreux with two goals in the first 10 minutes, and
There was understandably little urgency from the top-flight side in the second period and Hicham Tabate pulled a goal back, but
Lorient downed Chauray by the same scoreline,
Le Mans was beaten 2-1 by
Elsewhere, there were wins on penalties for Moulins, Venissieu and Vertou in their respective away ties against Marseille Consolat, Savigneux Montbrison and St Malo.
Raon-l'Etape beat Amneville 2-1 thanks to an extra-time winner from Tresor Nyamwisi, Amneville having forced extra-time with a late Mohamed Belameiri penalty, while Baldy Dia's goal earned Bordeaux Stade a 1-0 win over Carquefou.