With Cristiano Ronaldo unlikely to catch Ciro Immobile in the Serie A goalscoring charts, he could be given a break on Saturday.
Juve have already secured the Scudetto, their ninth in a row, and are just a week away from the second leg of their Champions League last-16 tie with Lyon, with a 1-0 deficit to overturn.
Ronaldo has not missed a game since the return of Italian football from the coronavirus-enforced break in June, the 35-year-old having taken his goal tally to 31 in the league to propel Juve to the title.
However, with Lazio striker Ciro Immobile four goals clear in the race to finish as top scorer, Sarri could give Ronaldo and others a well-deserved rest ahead of the Lyon clash.
Midfielder Aaron Ramsey may feature with a view to being fully fit to face the Ligue 1 side next week, although Paulo Dybala's recovery from a thigh problem is ongoing.
"We'll assess [who will play] today and tomorrow morning, depending on who needs to rest and who is fit to play," Sarri said on Friday.
"Between tomorrow and next Friday there will be a big difference in terms of mentality. We'll need to be good at recovering all energies possible.
"Tomorrow, whoever is fit will play and we'll try to make it a day of celebration. I can see two light-hearted teams tomorrow evening, with clear heads: a beautiful game can come out of it.
"Let's see how Cristiano feels for tomorrow, he's one of the players that played the most in the entire season. With regards to Aaron Ramsey, he might be back with the team today and there are good possibilities that he plays in the Champions League.
"Dybala is with the medical staff, everything is proceeding well, but I don't know when he'll be back with the group."