Santos and Unversidad de Chile progressed to the semi-finals of the Copa Libertadores after penalty shootout wins over Velez Sarsfield and Libertad respectively.
In Brazil, defending champion Santos beat 10-man Velez Sarsfield 1-0 in the second leg of its quarter-final tie with Alan Kardec netting on 78 minutes.
With the scores level after 90 minutes the game was decided by spot kicks - under competition rules no extra time is played.
Goalkeeper Rafael kept out Emiliano Papa's effort as the host won through 4-2 to set up a final four clash with Corinthians.
"Velez were very difficult rivals, but I think we deserve the qualification. Now we have to work harder because Corinthians will be a harder challenge," Rafael said.
"I know that some people want us to play in a bigger stadium but we must be hosts here in Vilha Belmiro. Here the pressure for the visitors is huge."
Velez played a man down from the 40th minute when goalkeeper Marcelo Barovero was sent off after a reckless tackle on Neymar outside the box as both raced for a loose ball.
In Santiago, Universidad de Chile drew 1-1 with Paraguay's Libertad with the goals arriving in the first half.
The home side went ahead on 18 minutes through Marcelo Diaz but an own goal five minutes later from Oscar Gonzalez levelled the score in the second leg and on aggregate.
Chilean keeper Johnny Herrera made several important saves, including one from the last move in normal time when he stopped a powerful shot by Rodolfo Gamarra.
In the shootout Herrera saved from Victor Hugo Ayala as his side won through 5-3.
The Chilean side next meets Boca Junior with a place in the final up for grabs.