Pachuca and Pumas UNAM qualified for Mexico's Liga MX play-offs after recording respective victories.
Colombian Aviles Hurtado came off the bench and struck in the second minute of injury time as Pachuca defeated lowly Veracruz 1-0 on Sunday (AEDT).
Unmarked substitute Hurtado headed the ball into the bottom corner of the net at the Estadio Miguel Hidalgo as Pachuca won for the first time in four outings.
At the Estadio Olimpico Universitario de Colima, three goals in the opening 16 minutes helped Pumas to a 4-2 win over sixth-placed Monterrey on Monday (AEDT).
Mexican striker Eduardo Herrera was the hero, netting twice for the home team against Monterrey, which is already assured of a place in the play-offs.
Pachuca (25 points, +2) and Pumas (24 points, +4) finished seventh and eighth respectively, replacing Santos Laguna (23 points, -1) and Leon (22 points, +2), which both failed to win over the weekend.
Laguna twice surrendered a lead, conceding in the 90th minute as Puebla earned a 3-3 draw.
Veteran Cuauhtemoc Blanco, 41, struck the equaliser having put Puebla on level terms just past the hour-mark.
Defending champion Leon, which was reduced to 10 men in the first half, lost 3-2 at Tijuana.
Chiapas - fifth in the standings - secured its spot in the play-offs thanks to a 2-1 victory over Ronaldino's Queretaro.
In other results, leaders America's (31 points, +10) winless run extended to four games after it was beaten 2-1 by third-placed Atlas (31 points, +2).
Second-placed Tigres UANL (31 points, +8) was a 2-1 winner over Toluca, which dropped to fourth.
Omar Bravo scored twice as Guadalajara edged basement side Morelia 2-1, while Universidad Guadalajara and Cruz Azul played out a 1-1 draw.