Lionel Messi will not feature for Barcelona in their La Liga clash with Malaga on Sunday (AEDT) due to "personal reasons".
Argentina international Messi has been replaced in the squad for the clash at La Rosaleda - which pits the league leaders against the bottom side - by centre-back Yerry Mina.
It will be the first La Liga match the 30-year-old has missed this season and just the fourth in total after he sat out their first three games in the Copa del Rey.
"Change to the squad. Messi is out for personal reasons and Yerry Mina takes his place," a statement from Barca's Twitter account read.
No further information on the reason for Messi's absence has been supplied.
Barca take on Chelsea in the second leg of their UEFA Champions League last-16 tie at Camp Nou on Thursday.