Medellin moved to the top of the Colombian Primera A table with a narrow 1-0 win over Uniautonoma.
Medellin replaced Deportivo Cali at the summit after its victory as the forme leaders lost at Patriotas Boyaca.
Hernan Torres' side eventually saw off Uniautonoma on Thursday (AEST) thanks to Andres Mosquera's 68th-minute goal.
The defender had not scored since September 2013 but his effort proved crucial for the new table-topper.
Cali - which overtook Once Caldas in the league lead last week - quickly relinquished its advantage with a 1-0 loss in Tunja on Friday (AEST).
Jonathan Estrada Campilo scored the only goal of the game in the 34th minute for Patriotas.
Cali has now dropped to fourth - Santa Fe and Caldas overtaking it.
Santa Fe cruised to a 2-0 win over rock-bottom La Equidad while Caldas was emphatic in a 4-1 triumph against Boyaca Chico.
The score was locked at 1-1 before Gustavo Culma's goal on the stroke of half-time changed the complexion of the match.
Jaime Ramirez and Cristian Palomeque added goals in the last 15 minutes for Caldas.
Fortaleza moved four points away from the foot of the table after Jhonathan Caicedo Vergara's 86th-minute strike gave it a 2-1 home win over Alianza Petrolera.
Aguilas Pereira snapped a run of three straight losses with a 4-2 win over Millonarios.
Elsewhere, Junior edged Deportes Tolima 1-0 and Atletico Huila and Envigado played out a 1-1 draw.