Inter Milan can bounce back from Monday's (AEST) Serie A humbling against Cagliari when it hosts Qarabag in the UEFA Europa League on Friday (AEST).
Walter Mazzarri's side was beaten 4-1 at San Siro - conceding all four goals in the first half - as Inter's stuttering start to the league continued at the weekend.
However, with the Inter coach demanding a response, Friday's (AEST) visit of Group F opponent Qarabag represents the ideal opportunity.
Inter has won all three of its European outings this season, scoring 10 goals without reply, while its Azerbaijani opponent approaches its 50th UEFA fixture off the back of an eight-game undefeated run in all competitions.
"We just need to work, get back up again quickly, show our spirit and fight like a great team does," Mazzarri stressed.
"We have to start again and be strong for the Europa League clash on Thursday."
Saint-Etienne and Dnipro Dnipropetrovsk contest the group's other fixture, while Dieter Hecking will hope to see an improved showing from his Wolfsburg side against Lille in Group H.
Hecking was less than impressed after his side's 4-1 reversal against Everton in its opening group game and will take charge of Wolfsburg's first European home fixture since the 2009-2010 quarter-final against Fulham.
Lille has failed to win any of its last nine Europa League matches on the road. Everton, meanwhile, is eager to extend its lead at the top when it travels to European debutant Krasnodar.
Lucien Favre takes Borussia Monchengladbach to former club Grasshopper Zurich in Group A as leader Apollon will look to deny Villarreal at 10th successive home win in the competition.
Marek Hamsik will return to the club he started his career with when Napoli travels to Slovan Bratislava looking to keep pace with Young Boys, who currently lead Group I on goal difference.
The Swiss side was a 5-0 winner against Slovan last time out and can bolster its hopes of progression with maximum points against Sparta Prague.
Group stage debutans Guingamp will hope to get its first points on the board against PAOK in Group K, where rival Fiorentina and Dinamo Minsk also meet in Belarus.
Trabzonspor will be out to beat Legia Warsaw for the third time in two seasons, after a solid start to Vahid Halilhodzic's reign, while Metalist and Lokeren can get up and running in Belgium.
Group B's top two are on the road as Copenhagen and Club Brugge travel to Torino and HJK respectively. In Group C, all four sides sit level on points and goal difference.
Tottenham hosts Besiktas and Asteras Tripolis welcomes Partizan, with Group D leader Dinamo Zagreb taking on Scottish champion Celtic. Salzburg takes on Romanian side Astra.
Group E pacesetter Dinamo Moscow and PSV Eindhoven meet in the Russian capital and Panathinaikos plays Estoril in the group's other fixture.
Rijeka and Feyenoord boast home advantage against holder Sevilla and Standard Liege respectively, while Steaua Bucharest takes on Dynamo Kiev and AaB entertains Rio Ave.