Robert Lewandowski will miss both UEFA Champions League quarter-final clashes with Paris Saint-Germain after Bayern Munich confirmed he is to be sidelined for a month with a knee injury.
Lewandowski sustained damage to his right knee during Poland's 3-0 FIFA World Cup qualifying win over Andorra on Monday (AEDT), a game in which he scored twice.
Poland subsequently confirmed he was to play no part in the upcoming clash with England and that he was due to return to Bayern for treatment.
It was initially thought the 32-year-old would only be absent for up to 10 days, however, Bayern confirmed on Wednesday that the issue is slightly more serious than first suspected.
A statement revealed Lewandowski is now expected to be out for most of April.
It read: "Robert Lewandowski has strained a ligament in his right knee. The FC Bayern striker will be out for around four weeks.
"After Poland's 3-0 win over Andorra, Lewandowski returned early to Munich, where a diagnosis was made by the German record champions' medical team."
While losing Lewandowski for so long would be a major blow regardless of the opponents Bayern have lined up, his forced absence comes at a particularly critical moment in the season.
The reigning Bundesliga champions face title rivals RB Leipzig this weekend, before meetings with PSG in the Champions League either side of Union Berlin's visit.
Those contests with PSG will be repeats of last season's Champions League final, which Bayern emerged from as 1-0 victors last August.
Losing Lewandowski will cause Bayern significant concern in attack, with their squad not possessing another senior central striker, meaning either Thomas Muller will be moved in to deputise or Eric Maxim Choupo-Moting will take on a more important role for the time being.
On a personal level, losing a month of the season could derail Lewandowski's hopes of breaking Gerd Muller's record of 40 goals in a single Bundesliga campaign.
The former West Germany star achieved the feat in 1971-72 with Bayern and Lewandowski is just five adrift, having netted 35 in 25 games this term.
Assuming Lewandowski is out for exactly four weeks, he will have three matches to score five or more goals – those games coming against Borussia Monchengladbach, Freiburg and Augsburg.