America fullback Miguel Layun sensationally scored four goals as the Liga MX leader put Santos Laguna to the sword.
Layun upstaged strikers Oribe Peralta and Michael Arroyo as he fired America to a 4-1 win in round 10 of the Apertura at Estadio Nuevo Corona.
The Mexico international broke the deadlock four minutes before half-time, half-volleying past Santos Laguna goalkeeper Oswaldo Sanchez after a corner was flicked on to the back post.
Layun doubled America's lead nine minutes into the second half, catching Sanchez well off his line from outside the penalty area after the keeper stormed off his line.
He completed his hat-trick on the hour-mark, when he side-footed home after superb work from Arroyo on the byline.
Carlos Izquierdoz pulled a goal back for the host in the 70th minute, though Layun restored the visitor's three-goal lead in the closing stages.
Back-to-back wins has America four points clear of Monterrey, which has a game in hand.
Monterrey overcame Atlas 2-1 thanks to Lucas Silva's first-half brace.
Silva scored twice in 26 minutes as Monterrey leapfrogged Atlas into second position.
Ronaldinho took his place in the Queretaro starting XI but it still drew 1-1 at home to fourth-placed Toluca.
The Brazil icon was in doubt for the league fixture after missing Queretaro's midweek Copa MX match due to a stomach bug.
But Ronaldinho was deemed fit enough to play as Camilo Sanvezzo's 45th-minute penalty cancelled out Pablo Velazquez's opener.
In other results, Leon's horrendous season continued as it was beaten 1-0 by Cruz Azul.
Mariano Pavone's strike condemned the defending champion - languishing third from bottom - to a fourth defeat in five games.
Tigres UANL climbed up to fifth after coming from behind to beat Pachuca 3-2.
Rock-bottom Morelia finally claimed its first win of the season, downing Universidad Guadalajara 2-1, while nine-man Veracruz held on to defeat Tijuana 1-0.
Chiapas scored twice in the final 10 minutes to draw 2-2 at Pumas UNAM and Guadalajara played out a goalless stalemate against Puebla.