Ronald Koeman will return to one of his former clubs for his first European game with Southampton after it was drawn against Vitesse in the third qualifying round of the UEFA Europa League.
Koeman led Southampton into Europe in his first season in charge as the south-coast club finished seventh in the Premier League.
And his immediate reward is a tie with Vitesse, a club he managed from 2000 to 2001 and one that qualified for the competition via the Eredivisie's play-off system.
Southampton's domestic rival West Ham may not have to leave the British Isles if it makes it to the next round, having taken a 1-0 first-leg advantage against Birkirkara.
Should the London club progress it could meet Inverness Caledonian Thistle, providing the Scottish side come through a tie with Astra of Romania, which is ahead 1-0 from the opening fixture.
Thomas Tuchel's first competitive game as Borussia Dortmund coach will be against Shakhtyor Soligorsk of Belarus or Wolfsberger, with the Austrian side 1-0 up after the first leg.
Athletic Bilbao, finalist in 2011-12, are set to meet either FH or Inter Baki, while Serie A side Sampdoria has been handed a tie against Vojvodina or Spartaks.
Saint-Etienne will take on Targu Mures and its Ligue 1 rival Bordeaux is to face Cypriot outfit Larnaca. AZ starts its campaign against Istanbul Basaksehir.
The first legs are scheduled for 30 July, with the return fixtures set for 6 August.
The draw in full:
Zurich v Cherno More
Kairat Almaty/Alashkert v Rijeka/Aberdeen
Dacia Chisinau/Zilina v Poltava
AZ v Istanbul Basaksehir; Bordeaux v Larnaca
Lokomotiv Zagreb/PAOK v Spartak Trnava/Linfield
Sampdoria v Vojvodina/Spartaks
Slovan Liberec v Hapoel Kiryat Shmona
Athletic Bilbao v FH/Inter Baki
Targu Mures v Saint-Etienne
Kukesi/Mladost Podgorica v Legia Warsaw/Botosani
Cukaricki/Qabala v Apollon/Trakai
Jelgava/Rabotnicki v Trabzonspor/Differdange
Skonto/Debrecen v KR/Rosenborg
Charleroi/Beitar Jurusalem v Zorya
Shakhtyor Soligorsk/Wolfsberger v Borussia Dortmund
Beroe/Brondby v Jagiellonia Bialystok/Omonia
Jablonec v Copenhagen/Newtown
Sturm Graz v Rubin Kazan
Solna/Shirak v Atromitos
Altach v Vitoria Guimaraes
Hapoel Beer Sheva/Thun v Vaduz/Nomme Kalju
Randers/Elfsborg v Shamrock Rovers/Odd
Standard Liege v Ferencvaros/Zeljeznicar
Koper/Hajduk Split v Mlada Boleslav/Stromsgodset
Belenenses v Slask Wroclaw/Gothenburg
Southampton v Vitesse
West Ham/Birkirkara v Inverness Caledonian Thistle/Astra
Krasnodar v Slovan Bratislava/UCD