New coach Ronald Koeman has named five uncapped players in the Netherlands squad for his first internationals in charge, signaling that he is going to shake up a team which failed to qualify for two consecutive major tournaments.
The newcomers in Koeman's 25-man squad include 18-year-old Ajax winger Justin Kluivert, the son of former Netherlands striker Patrick Kluivert, who also was 18 when he made his debut and went on to score 40 goals in 79 internationals.
Koeman's other new names are three AZ players - goalkeeper Marco Bizot, midfielder Guus Til and striker Wout Weghorst. The final new face was Hans Hateboer of Atalanta.
There was no place for veteran Feyenoord striker Robin van Persie and it was the first squad since midfield playmaker Wesley Sneijder announced his retirement from international football after talks with Koeman.
The Netherlands take on England on March 23 in Amsterdam and Portugal three days later in Geneva.
With the team having failed to qualify for this year's FIFA World Cup in Russia, Koeman has time to experiment as he seeks his strongest team.
Goalkeepers: Marco Bizot (AZ), Jasper Cillessen (Barcelona), Jeroen Zoet (PSV Eindhoven)
Defenders: Patrick van Aanholt (Crystal Palace), Nathan Ake (Bournemouth), Virgil van Dijk (Liverpool), Timothy Fosu-Mensah (Crystal Palace), Hans Hateboer (Atalanta), Matthijs de Ligt (Ajax), Kenny Tete (Lyon), Stefan de Vrij (Lazio)
Midfielders: Donny van de Beek (Ajax), Davy Proepper (Brighton & Hove Albion), Marten de Roon (Atalanta), Kevin Strootman (Roma), Guus Til (AZ), Tonny Vilhena (Feyenoord), Georginio Wijnaldum (Liverpool)
Forwards: Ryan Babel (Besiktas), Steven Berghuis (Feyenoord), Memphis Depay (Lyon), Bas Dost (Sporting), Justin Kluivert (Ajax), Quincy Promes (Spartak Moscow), Wout Weghorst (AZ)