Manchester United midfielder Shinji Kagawa has been ruled out of Japan's 2014 FIFA World Cup qualifier in Oman on 14 November due to a knee injury he suffered a week ago, the Japan Football Association said.
Kagawa was not among the 18 Europe-based players who coach Alberto Zaccheroni planned to call up for his 23-man squad for the Oman game, the association said.
The 23-year-old northern summer signing was injured in Manchester United's 3-2 UEFA Champions League win over Braga on 23 October.
Among the 18 Europe-based players are regulars such as CSKA Moscow playmaker Keisuke Honda and Inter Milan defender Yuto Nagatomo. Japan also included Southampton striker Tadanari Lee, who has not played for his country since suffering an ankle injury in March.
In World Cup qualifying, Japan is leading Asian Group B with 10 points from three wins over Oman, Jordan and Iraq as well as one draw with Australia.