Three-time winner Inter has been pitted against Icelandic minnow Stjarnan in the play-off round of the UEFA Europa League.
Inter won the competition on three occasions in the 1990s under its UEFA Cup guise and will be hoping to do so again this season under Walter Mazzarri.
However, it will need to be wary of a Stjarnan team that claimed a surprise 1-0 aggregate win over Lech Poznan to reach the final qualifying stage.
Like Inter, Tottenham and Feyenoord are fancied to challenge for Europa League honours and will start their respective quests against AEL and Zorya.
Last season's FA Cup finalist Hull City, which scraped past Trencin 2-1 on Friday (AEST), will continue its maiden European adventure against Belgian outfit Lokeren.
Polish side Legia Warsaw was demoted from the UEFA Champions League on Friday for fielding an ineligible player in the second leg of its 6-1 aggregate victory over Celtic, has been progressed to the play-off stage of the tournament by default.
The gulf between the two competitions was perfectly illustrated as Legia was handed a meeting with Aktobe of Kazakhstan.
Torino, competing in Europe for the first time in 20 years, was rewarded for a 7-0 aggregate triumph over Brommapojkarna with a tie against RNK Split, while Real Sociedad will take on Russian team Krasnodar.
Meanwhile, Borussia Monchengladbach faces Sarajevo and Lyon and PSV have been drawn against Astra and Shakhtyor respectively.
The first legs are to be played on 21 August, with the return legs taking place seven days later.
Draw in full:
Sarajevo v Borussia Monchengladbach, Spartak Trnava v Zurich, Qarabag v Twente, Neftci v Partizan, RNK Split v Torino, Asteras Tripolis v Maccabi Tel-Aviv, Omonia Nicosia v Dinamo Moscow, Apollon v Lokomotiv Moscow, Petrolul v Dinamo Zagreb, Aktobe v Legia Warsaw, Ruch Chorzow v Metalist, Astana v Villarreal, HJK v Rapid Vienna, Lyon v Astra, Elfsborg v Rio Ave, Young Boys v Debrecen, AEL v Tottenham, Dinamo Minsk v Nacional, Trabzonspor v Rostov, Lokeren v Hull City, PSV v Shakhtyor, Zwolle v Sparta Prague, Dnipro v Hajduk Split, Zimbru v PAOK, Karabukspor v Saint-Etienne, Stjarnan v Inter, Panathinaikos v Midtjylland, Feyenoord v Zorya, Grasshopper v Club Brugge, Real Sociedad v Krasnodar, Rijeka v Sheriff.