Barcelona forward Antoine Griezmann has suffered a thigh muscle injury, the La Liga club have confirmed.
The France international was replaced by Luis Suarez at half-time of Sunday's (AEST) 1-0 victory away to Real Valladolid.
Medical tests on Sunday showed Griezmann has damaged the quadriceps in his right leg and is facing a spell out of action.
The 2018 FIFA World Cup winner, a €120 million (A$195 million) signing from Atletico Madrid last year, is likely to miss Friday's league match against Osasuna at Camp Nou.
Griezmann has scored just nine goals in 35 league appearances during a difficult first season with Barca.
He was dropped from the starting line-up by coach Quique Setien for the 2-2 draws with Celta Vigo and Atleti last month but made a goalscoring return in the 4-1 win over Villarreal on July 6.