Barcelona rising star Ansu Fati has been called up to the Spain squad for next month's matches against Germany and Ukraine.
Wolves winger Adama Traore is another uncapped player to be included, having missed out on making his international debut last November due to injury.
In something of a fresh-faced squad, head coach Luis Enrique has also added Manchester City defender Eric Garcia and Real Madrid midfielder Oscar Rodriguez, who has been on loan at Leganes.
There are also places for new Manchester City signing Ferran Torres, Athletic Bilbao goalkeeper Unai Simon, Real Sociedad midfielder Mikel Merino and Sevilla full-back Sergio Reguilon, another Madrid loanee.
Barcelona left-back Jordi Alba has been left out and there are no players from Atletico Madrid in the squad.
September's games will be Spain's first since last year, with international matches in March having been called off due to the coronavirus pandemic.
They head to Stuttgart to face Germany on September 3 before hosting Ukraine three days later.
Spain squad in full: David de Gea (Manchester United), Kepa Arrizabalaga (Chelsea), Unai Simon (Athletic Bilbao); Jesus Navas (Sevilla), Dani Carvajal (Real Madrid), Sergio Ramos (Real Madrid), Pau Torres (Villarreal), Diego Llorente (Real Sociedad), Jose Gaya (Valencia), Sergio Reguilon (Sevilla), Eric Garcia (Manchester City); Fabian Ruiz (Napoli), Thiago Alcantara (Bayern Munich), Sergio Busquets (Barcelona), Rodri (Manchester City), Mikel Merino (Real Sociedad), Dani Olmo (RB Leipzig), Oscar Rodriguez (Leganes); Rodrigo Moreno (Valencia), Mikel Oyarzabal (Real Sociedad), Adama Traore (Wolves), Marco Asensio (Real Madrid), Ansu Fati (Barcelona), Ferran Torres (Manchester City).