Manchester United and Arsenal were handed tricky UEFA Europa League last-32 ties against Club Brugge and Olympiacos respectively, while Inter Milan take on Ludogorets.
Ole Gunnar Solskjaer's United side face Belgian outfit Brugge, who finished third in a UEFA Champions League group including Paris Saint-Germain and Real Madrid.
The Red Devils, winners of the competition in 2016-17, topped their Europa League pool, losing just once with a youthful side at Astana.
Struggling Arsenal will have been eyeing a more favourable draw than Olympiacos, who are familiar with north London having faced Tottenham in the Champions League.
Inter were unfortunate not to make the last 16 of the Champions League, losing out to Barcelona and Borussia Dortmund, but Antonio Conte's side will fancy their chances against Bulgarian side Ludogorets.
Sevilla, who are the competition's most successful club, with five wins across the UEFA Cup and Europa League, will have to overcome Cluj to make the last 16.
Old Firm duo Celtic and Rangers take on Copenhagen and Braga, while Premier League side Wolves lock horns with LaLiga strugglers Espanyol.
Ajax, Champions League semi-finalists last season, also face Spanish opposition in the form of Getafe, and Roma – who reached the last four of Europe's premier competition in 2017-18 – go up against Gent.
Bayer Leverkusen take on two-time winners Porto in one of the round's stand-out ties, as Shakhtar Donetsk and Benfica – two demoted Champions League outfits – face off.
Having impressed against Liverpool and Napoli, Salzburg play Eintracht Frankfurt.
First-leg games take place on February 20, with the return fixtures a week later.
The full draw for the Europa League's round of 32:
Wolves v Espanyol
Sporting CP v Istanbul Basaksehir
Getafe v Ajax
Bayer Leverkusen v Porto
Copenhagen v Celtic
APOEL v Basel
Cluj v Sevilla
Olympiacos v Arsenal
AZ v LASK Linz
Club Brugge v Manchester United
Ludogorets v Inter
Eintracht Frankfurt v Salzburg
Shakhtar Donetsk v Benfica
Wolfsburg v Malmo
Roma v Gent
Rangers v Braga
Club chiefs will return to Nyon for the last-16 draw on February 28.