Atletico Madrid forward Moussa Dembele has tested positive for coronavirus.
La Liga leaders Atletico confirmed the news on Friday (AEDT), a day after record signing Joao Felix returned a positive test.
"Our squad underwent PCR tests on Wednesday as recommended by La Liga, in addition to the first weekly antigen tests outlined in their protocol. The PCR test showed that Moussa Dembele is positive for COVID-19," Atletico said in a statement.
"The Frenchman is isolating at home, in compliance with the health authorities' guidelines and La Liga protocols."
Atleti face Celta Vigo at home next Tuesday as they look to build on their 10-point lead at the top of the table.
Dembele joined from Lyon last month on loan until the end of the season, with Atleti retaining an option to buy the former France Under-21 international for an initial fee of €33.5 million (A$52.8 million).
He has been on the bench three times in La Liga but is yet to make an appearance under coach Diego Simeone.