Kevin De Bruyne's ankle injury sustained in the FA Cup semi-final loss to Chelsea "doesn't look good", according to Manchester City boss Pep Guardiola.
The Belgium international went off in the 48th minute as City's quadruple hopes were ended by Hakim Ziyech's second-half goal in a 1-0 defeat at Wembley on Sunday (AEST).
De Bruyne will undergo tests on Monday to determine the severity of his injury, with the EFL Cup final against Tottenham coming next weekend and the first leg of their Champions League semi-final against Paris Saint-Germain following three days later.
Asked about De Bruyne's status, Guardiola told a news conference: "He has pain now. Tomorrow they are going to make a test with the doctors. It probably doesn't look too good but tomorrow we will see what he has."
De Bruyne was one of only three City players to retain their place in the starting line-up from the midweek victory over Borussia Dortmund.
Guardiola rejected the suggestion that his widescale rotation signified a lack of respect for the FA Cup.
"We had two days to recover [after Dortmund] and played away and had to travel by train for three hours [to Wembley] and everyone deserves to play, but don't say we don't pay attention," Guardiola said.
"A team that arrives in the final stages of all competitions couldn't say that. This team won four finals in a row in the Carabao Cup, so just say we lost the game and when we lost the game the decision is bad. But it's such a poor argument.
"We wouldn't get to the semi-finals of the FA Cup or the final of the Carabao Cup and semi-finals of the Champions League if we didn't pay attention. This team always plays to win.
"It was a tight game. Congratulations to Chelsea, they're a top side. But if you believe we didn't pay attention, what would happen if we won today with eight changes? Say it before the game, say 'Pep doesn't pay attention' or 'the players don't pay attention'. Don't just say it after because we lost a game.
"These guys in 10 months, 11 months fight every game like I've never seen. We lose a game against a top side and now we don't pay attention or care about this competition? We respect a lot the FA Cup, we play to win."