Cruzeiro and Internacional were among the teams to advance to the Copa Libertadores quarter-finals while Atletico Mineiro was eliminated.
Cruzeiro edged Brazilian rival Sao Paulo on penalties after Leandro Damiao scored a 55th-minute goal saw it claim a 1-0 win in the second leg.
But with the tie level, penalties were needed and Marcelo Oliveira's men came out on top 4-3 in the shoot-out.
Cruzeiro needed a goal and it came via Damiao but thanks largely to an exquisite pass from Willian.
Willian put Mayke in behind down the right with a defence-splitting pass and the full-back squared for Damiao to tap in.
Damiao failed to net from the penalty spot with his team's first effort in the shoot-out as Rogerio Ceni saved his tame spot-kick down to his right.
With Sao Paulo 2-1 up, Souza blazed his penalty over the bar.
Luis Fabiano and Manoel had penalties saved before Gabriel Xavier sealed Cruzeiro's win with a well-placed effort.
Internacional sent Atletico Mineiro packing after a 3-1 second-leg win gave it a 5-3 victory on aggregate.
First-half goals from Valdivia and Andres D'Alessandro set up Internacional's win, with Lucas Pratto and Lisandro Lopez trading goals after the break.
Guarani completed a 3-0 aggregate triumph over Corinthians with a 1-0 win away from home.