Club Universitario picked up where it left off in the Liga del Futbol Profesional Boliviano, while Blooming also won on the first matchday.
Last season's Clausura champion Club Universitario opened the campaign with a 3-0 win at home to Universitario Cobija.
Diego Cabrera, Mauricio Saucedo and Diego Rivero were on the scoresheet for Javier Vega's men.
Cabrera opened the scoring in the 27th minute, Saucedo netted from the penalty spot on the hour-mark and Rivero struck the sealer.
It sits top of the table thanks to its goal difference, but Blooming, San Jose and The Strongest also claimed first-up wins.
Goals from Martin Minadevino and Matias Manzano in the first 26 minutes saw Blooming to a 2-0 win over Nacional Potosi.
San Jose edged Bolivar 1-0, while The Strongest claimed a hard-fought 1-0 victory over Sport Boys.
Elsewhere, Omar Morales equalised twice for Petrolero Yacuiba as it drew 2-2 at Wilstermann.
Real Potosi's hosting of Oriente Petrolero finished goalless.