Spain captain Sergio Ramos has not been included in Luis Enrique's Euro 2020 squad after an injury-troubled 2020-21 season.
Aymeric Laporte, who only this month switched his allegiance from France to Spain, is among the centre-back options to have been preferred to the veteran.
Ramos was part of the national team that won three consecutive major tournaments between 2008 and 2012 and has remained a key man for club and country ever since, breaking Italy great Gianluigi Buffon's all-time international appearances mark of 176 earlier this season.
The 35-year-old has had the armband for Spain under Luis Enrique but played only 50 minutes of the March World Cup qualifiers against Greece and Kosovo before returning to Madrid injured.
Ramos was limited to 21 appearances in all competitions for Madrid this term, missing 31 matches. Zinedine Zidane's side actually conceded more often (1.0 per game vs 0.8) with Ramos in the team.
Remarkably, former Barcelona coach Luis Enrique did not name a single Madrid player in his finals squad.
Right-back Dani Carvajal is injured, leaving Spain light in that area of the pitch where Atletico Madrid midfielder Marcos Llorente may deputise, while Los Blancos teammates Marco Asensio and Isco have fallen out of favour.
Madrid's Nacho is another centre-back ignored, with Manchester City pair Laporte and Eric Garcia preferred to he and Ramos despite spending much of the season behind Ruben Dias and John Stones in the pecking order at the Etihad Stadium.
French-born Laporte, City's premier defensive option prior to this season, has made 27 appearances in all competitions for the Premier League champions but is in line for an international debut after this weekend's Champions League final.
Garcia – widely expected to join Barca when his contract expires next month – was limited to just 12 outings and nine starts, with a solitary clean sheet.
Athletic Bilbao's Inigo Martinez was another absentee at centre-back, with Luis Enrique telling reporters: "About Inigo Martinez, after this press conference there will be a statement, and that'll make things clear."
Spain squad for Euro 2020:
Unai Simon (Athletic Bilbo), David De Gea (Manchester United), Robert Sanchez (Brighton and Hove Albion); Jose Gaya (Valencia), Jordi Alba (Barcelona), Pau Torres (Villarreal), Aymeric Laporte (Manchester City), Eric Garcia (Manchester City), Diego Llorente (Leeds United), Cesar Azpilicueta (Chelsea); Marcos Llorente (Atletico Madrid), Sergio Busquets (Barcelona), Rodri (Manchester City), Pedri (Barcelona), Thiago Alcantara (Liverpool), Koke (Atletico Madrid), Fabian Ruiz (Napoli); Dani Olmo (RB Leipzig), Mikel Oyarzabal (Real Sociedad), Alvaro Morata (Juventus), Gerard Moreno (Villarreal), Ferran Torres (Manchester City), Adama Traore (Wolves), Pablo Sarabia (Paris Saint-Germain)