Raheem Sterling's last-gasp effort extended City's lead above second-placed Manchester United back to eight points and caused wild scenes at the Etihad.
With Guardiola's players celebrating their victory on the pitch shortly after the full-time whistle, the Spaniard walked straight up to Redmond and, after a brief handshake, began to exchange some angry words with the England international.
"No discussions," Guardiola said of the incident during his post-match interview on Sky Sports.
"We just talk about how good a player he is and how quality he is (sic).
"Redmond and Sofiane Boufal are players who today just defended, but they are players with a lot of quality."
Manchester City will next face West Ham United on Monday (AEDT), while Southampton travel to Bournemouth.