Fox Sports won the English-language rights to air the 2018 and 2022 World Cups in the US from ESPN as part of a $400 million (A$512m) deal struck in 2011 when few would have predicted that the American team would fail to qualify for the 2018 tournament in Russia.
"Last night's World Cup qualifying results do not change FOX Sports' passion for the world's biggest sporting event," the company said in a statement.
"While the US was eliminated, the biggest stars in the world from Lionel Messi to Cristiano Ronaldo stamped their tickets to Russia on the same day, and will battle teams ranging from Mexico to England that have massive fan bases in America."
US dreams were dashed on Tuesday when they lost 2-1 to Trinidad and Tobago to finish fifth in the six-team North, Central American and Caribbean (CONCACAF) qualifying group.
"FOX Sports remains steadfast in our commitment of bringing the games to America for the first time in 2018 and will continue to support the U.S. Soccer Federation as they look ahead to the 2022 World Cup," the network said.
Sports marketing experts on Wednesday said that although not qualifying is undoubtedly a setback for US football, it does not spell disaster for Fox.
Reports indicating a US$10-20 million (A$12-24m) negative impact for Fox from the US team's failure to qualify seem correct and represent a negligible amount for the network, said Brian Wieser, an analyst with equity research company Pivotal.
"We think the absence of the men's team from the 2018 World Cup is negative, but only marginally so, and in line with reported estimates," he said.
"Arguably the challenging time zone (with the 2018 tournament hosted in Russia) will prove to cause a more significant factor depressing viewing when comparing 2018 vs. 2014," Wieser added.
Joe Favorito, a sports marketing consultant, said any company investing in football is investing in a global brand.
"When you walk down the streets of Manhattan today, you see kids wearing Messi jerseys and Ranoldo jerseys much more than you see them wearing American jerseys," he said.
"So people saying this is disastrous to Fox are being premature."
The real financial harm will come in the form of "collateral damage" to players like 19-year-old American Christian Pulisic, who could have used the World Cup platform to boost his personal brand.
The team's absence will also hurt US stadiums that would have hosted lead-up matches and grassroots football investment dollars that would have come from FIFA.
"That's the damage of this, not so much for the brands that would have bought into Fox," Favorito said.
"At the end of the day, it's going to be an amazing global event and that's what Fox bought into," he added.
"They didn't buy into the US winning the World Cup."