"Nothing is standing in the way of using VAR (at the World Cup), as far as I'm concerned," Infantino said in the Russian city of St Petersburg on the eve of the Confederations Cup final.
"So far it has been successful. We are learning, we are improving, we are continuing the tests."
VAR involves two video assistant referees watching the on-pitch action remotely and then drawing the match referee's attention to officiating mistakes.
FIFA said the system corrected six game-changing decisions during the Confederations Cup.
"Without the VARs, we would have had a different tournament," Infantino said. "And a tournament which would have been a little less fair."
But Infantino, who said that the system had been tested so far in 74 matches, added that certain aspects needed to be refined.
"We need to work still on some of the details, on the communication and the speed of the decisions being taken," he said.
The time needed to make decisions has been criticised. There has also been debate about which circumstances it should be used for as some close calls are decided without consulting the VARs.
The use of the system has caused controversy at times, such as during Germany's 3-1 group stage win against Cameroon when referee Wilmar Roldan needed two reviews of an incident to send off the correct Cameroon player.
Former World Cup final referee Pierluigi Collina, the chairman of FIFA's referees committee, said on Saturday that the system was a "very positive tool" to help referees make the right calls and took pressure off them.
Soccer's law-making body IFAB is expected to decide next March whether to allow video assistant referees to become part of the game on a permanent basis.
Chile face World Cup holders Germany in Sunday's Confederations Cup final.