While public attention will focus on the big matches in Australia, games between smaller teams will also be under scrutiny for potential manipulation by illicit betting rings.
Swiss-based Sportradar, which has a partnership with the AFC, will monitor for unusual betting patterns once the tournament starts on Friday, when the Socceroos play Kuwait in Melbourne.
While the overall risk of match-fixing at the tournament is considered low, smaller teams with lower-paid players are considered more vulnerable to match-fixers.
"Any time you have meaningless matches, pool games where the result means nothing, or teams where the players are poorly rewarded ... there is a risk," betting industry expert Scott Ferguson said.
Match-fixing, along with doping, is one of the biggest threats to the integrity of sport and is fuelled by a multi-billion dollar illegal betting industry.
A crackdown on several fronts has yielded results with scandals uncovered in Australia and England and a leading suspect now detained for more than a year in Singapore.
In 2013, Victorian police busted a $2 million Singaporean-based betting ring involving suburban Melbourne football club Southern Stars.
Last month, Vietnamese football officials raised concerns about their own national team after the AFF Suzuki Cup semi-final loss to Malaysia but no suspicious betting patterns were detected.
In November, Saudi club Al Hilal made an unsubtantiated cry of foul play over its AFC Champions League final defeat to Western Sydney Wanderers after a string of penalty appeals were waved away.
Ferguson, a ex-head of education at bookmakers Betfair who runs the Sport is Made for Betting website, said the risk of match-fixing at the Asian Cup was "fairly low" given the event's high profile and anti-corruption efforts in Australia.
But organisers remain on guard.
In September, Sportradar said betting patterns showed a strong likelihood of fixed football matches at the Asian Games.
Elsewhere, Japan's coach Javier Aguirre will appear in a Spanish court in February over strongly-denied accusations of match-fixing in 2011 when he was in charge at Real Zaragoza in Spain.
Scandals have been uncovered in many countries in Asia, including China, where officials were jailed in a mass clean-up, and South Korea, where a player committed suicide following revelations of fixing in the K-League.
Monitoring betting is a key weapon in the fight against fixed matches, giving an instant indication of whether a shock result is legitimate or possibly down to foul play.
"Shock results do actually happen ... it's only in recent years we ponder if there was anything suspicious behind it," Ferguson said.
"Highly sophisticated logarithmic models derive most betting markets these days.
"There will always be room for human adjustment on top of that ... but particularly in-play, the models will accurately predict what each team's respective chances are.
"When markets deviate from this and heavy monetary support continues to force prices further away from numbers derived from databases of tens of thousands of matches, alarm bells ring."
