Aris Thessaloniki was relegated from the Greek Superleague after a 2-0 home defeat against Ergotelis.
Giorgos Sarris and Dimitrios Diamantakos scored the goals for the visitor, which had Vladimir Stojkovic sent off three minutes from time.
The result left Aris 11 points adrift from the relegation play-off with only three games remaining and condemned it to the second tier for the first time since 2006.
Veria and Platanias boosted their survivial hopes as both claimed vital wins.
Platanias claimed a 2-0 win over Levadiakos while Veria beat Xanthi 3-2 and both clubs leapfrogged Apollon Smirnis who face PAOK on Thursday and now sit in the relegation zone.
Aleksandar Katai opened the scoring for Platanias and, despite the sending off of Konstatinos Kaznaferis in the 67th minute, the Serbian grabbed his second four minutes later.
It was an eventful affair at Veria as Branko Ostojic opened the scoring for the home side but Theodoros Vassilakakis levelled things up for Xanthi in the 33rd minute before being sent off nine minutes later.
Kenan Bargan and Charalampos Pavlidis then made it 3-1 before Ostojic and Dimitrios Amarantidis were handed their marching orders in stoppage-time and Stelios Nakas grabbed a consolation.
Panionios sit four points clear of Veria and Platanias after a 1-1 draw against Panetolikos with Christos Aravidis and Nicolas Martinez trading goals.
At the other end of the table, champion Olympiacos lost for the third time in five games when it went down 2-1 at Asteras Tripoli.
Pablo De Blasis put the home side ahead but Nikos Vergos grabbed an equaliser before Mauricio Carrasco grabbed a last-minute winner.
Second-placed Atromitos also suffered defeat as goals from Ze Eduardo and Dudu Cearense handed OFI a 2-0 win while Panathinaikos beat Kalloni AEL thanks to strikes from Athanasios Dinas, Nikos Karelis and an Efstratios Valios own goal.