Ajax and Roma face differing challenges if they are to reach the UEFA Europa League last 16.
Ajax carries a lead to Legia Warsaw in the last 32 and an unusual atmosphere is awaiting it in Poland.
Frank de Boer's men recorded a 1-0 win in the first leg thanks to Arkadiusz Milik's goal.
And an empty Stadion Wojska Polskiego awaits Ajax due to UEFA sanctions imposed on Legia Warsaw for racist behaviour.
The second leg against Ajax is the second game of that two-game ban.
De Boer said he was optimistic about his team's chances of progressing.
"I feel positive but we need to wait and see," he said.
"But if we play the same game we did in the first half, they’ll have a hard time.
"It's in our advantage that we kept a clean sheet. It’s in our own hands now and we need to ensure we go through.
"I give us a 60 per cent chance."
While the Eredivisie outfit holds an upperhand, Serie A giant Roma travels to Feyenoord after a 1-1 home draw.
Rudi Garcia's men have drawn three straight matches and need to turn their form around when they visit Rotterdam in front of an expected packed Kuip stadium.
Premier League sides Liverpool and Tottenham Hotspur both face second-leg tests away from home.
Liverpool heads to Besiktas with a 1-0 aggregate lead, while Fiorentina held Tottenham 1-1.
Everton is cruising against Young Boys, with Romelu Lukaku having inspired a 4-1 win in Switzerland.
Rafael Benitez's Napoli crushed Trabzonspor 4-0 in Turkey ahead of hosting the second leg.
Inter Milan and Celtic played out a thrilling 3-3 draw in Scotland, putting the Serie A side on top in the tie.
Elsewhere, PSV heads to Russia after suffering a 1-0 home loss to Zenit St Petersburg.
Club Brugge is 3-1 up ahead of hosting Aab, while Athletic Bilbao holds the upperhand over Torino after a 2-2 draw in Italy.
In-form Wolfsburg is 2-0 up heading to Sporting, Olympiacos needs to overturn a 2-0 deficit when it hosts Dnipro Dnipropetrovsk and Dinamo Moscow hosts Anderlecht after a 0-0 draw in Belgium.
Sevilla carries a 1-0 lead to Borussia Monchengladbach, Guingamp visits Dynamo Kiev after a 2-1 first-leg win and Villarreal is 2-1 up ahead of a trip to Salzburg.