Derided in many quarters for being a poor man's UEFA Champions League, the Europa League does not figure highly on the priority list of many top-flight managers.
But the competition remains one of the biggest prizes in football for Villas-Boas, who has vowed to put all his resources into bringing the trophy to White Hart Lane this season.
Two years ago Villas-Boas won the competition in
Things quickly went sour for the 34-year-old at Stamford Bridge, where he was sacked after nine months in charge.
Now, fresh from last weekend's morale-boosting win over Reading - his first in charge of Spurs - the Portuguese hopes to end his two-year drought by leading the London side to victory in the Europa League.
"It does seem a long time since I won it with Porto," Villas-Boas said. "A lot of things have happened since then. The memories are still present but at this time I can't live off the past.
"In our position we can't think too much about the past. In this life you constantly have to motivate yourself and put pressure on yourself to win more (trophies).
"This time it would be wonderful to win it again for Tottenham."
Villas-Boas could hardly have wished for a tougher opponent for Thursday evening's (Friday morning AEST) Group J opener.
Lazio, blessed with the talents of Brazilian playmaker Hernanes and Germany striker
Given that the likes of Manchester United, Manchester City and Ajax dropped into the competition last season, Villas-Boas has a point when he says the Europa League is an extremely tough competition to win.
And he feels the winner could therefore be entitled to a bigger prize - such as direct qualification into the Champions League the following season.
"That idea was raised on the
"It's an extremely important competition after the disappearance of the Cup Winners' Cup and it should be treated with respect.
"It's full of history and different winners. It does not generate financial advantages for the clubs in it but it generates emotions when you win it. It's about emotion and the fans and they would be extremely happy if that happens."
Villas-Boas has vowed to name a strong side for the game, but will make a few changes to the side which beat Reading 3-1.
Lloris has endured something of a turbulent start to his career at White Hart Lane.
Villas-Boas publicly vowed to stick by
The Spurs boss held a clear-the-air meeting with his £8 million ($12.44 million) signing last week and said: "The first two days after the international week (and before the Reading game) were more like recovery days for him.
"From then on he was training more with (goalkeeping coach)
"The only thing we can say is that his talent is immense and easily visible from the time he has trained with us."
Benoit Assou-Ekotto will see a specialist before the end of the week to determine if he needs a knee operation, while
UEFA Europa League
Malaga playmaker Isco has vented his anger and frustration after the Court of Arbitration for Sport dismissed the Andalusian club's appeal against a ban preventing it from playing in European competition next season.