Real Madrid star Sami Khedira will miss the next two weeks and both his club's Champions League clash with Dortmund, then Germany's friendly with The Netherlands, after picking up a new leg injury.
The 25-year-old defensive midfielder limped out of Real's 2-1 defeat at Dortmund in midweek in the Champions League clutching his left hamstring.
It was his first game back after injuring himself in the World Cup qualifier win in Ireland on October 11.
Having also missed Germany's 4-all draw with Sweden in last week, Khedira is now set to sit out the next fortnight and will miss Real's return Champions League clash against Dortmund in Madrid on November 6 with his team second in Group D.
He is also unlikely to be fit for Germany's international friendly against The Netherlands in Amsterdam on November 14.
Since joining Real after the 2010 World Cup, this is Khedira's eighth injury.