Champion Real Madrid is aiming to get its La Liga campaign back on track away to city rival Rayo Vallecano.
Real has had a dismal start which has seen Lionel Messi-inspired Barcelona open up an eight-point lead over it with the season little over a month old.
Many reasons have been offered for the run of just one win in four games, from a demanding pre-season tour to claims Jose Mourinho has lost control of the dressing room.
But Real did offer the motivation and fight that had been missing to come from behind to beat UEFA Champions League opponent Manchester City at the Bernabeu on Wednesday.
Defeat away to Sevilla last weekend, however, means Real has picked up only four points so far and afterwards an angry Mourinho was particularly disappointed with the manner of the defeat where the players appeared to lack interest.
Sergio Ramos, one of the heavyweights in the Madrid dressing room and someone who has stood up to Mourinho in the past, appeared to be the one to pay the price as he was dropped against City and Raphael Varane came in to partner Pepe at centre half.
The pressure on the shoulders of the Portuguese coach would really have increased with a further defeat which looked quite possible at 2-1 down with six minutes to go but Karim Benzema and Cristiano Ronaldo turned the game around.
"We knew that we were not playing well and we didn't need the trainer to tell us that," said defender Alvaro Arbeloa.
"There is a very good relationship in the dressing room and we are in agreement with the coach. Now after that important win (against City) we need to keep going."
Most of the question marks at the start of the season were over how Barcelona would be able to overturn Madrid with its new coach Tito Vilanova, and with Messi leading the way it has made a storming start with four straight wins in the league and now plays Granada at the Camp Nou.
Messi also proved his value on the European stage with two late goals as Barca too had to come from behind to beat Spartak Moscow on Thursday.
The main concern for Vilanova is the number of players missing from the defence with Gerard Pique adding to the list against Spartak which saw Alex Song come on to partner Javier Mascherano at the back.
Carles Puyol and Jordi Alba were also out along with long-term absentee Eric Abidal.
The off-field problems concerning Malaga have not affected its start to the season and it sits behind Barcelona on 10 points with Athletic Bilbao its next opponent.
Qatari owner Sheikh Abdullah al-Thani off-loaded some of the star players over the summer and was looking for buyers but the crisis now appears to have passed although he has cut back on investment.
Real's conqueror last weekend, Sevilla, now travels away to Deportivo la Coruna while Mallorca, which has also made a strong start, has a tough match with the visit of Valencia.
UEFA Europa League winner Atletico Madrid entertains promoted Valladolid which has slumped to back-to-back defeats.
At the foot of the table Osasuna and Espanyol both have just one point and now take on Zaragoza and Real Betis respectively.
Barcelona has announced that defender Adriano has signed a new four-year contract.