Iker Casillas and Xavi have received the annual sports prize from Spain's Prince of Asturias Foundation.
Casillas, of Real Madrid, and Xavi, with bitter rival Barcelona, have combined for 253 international appearances in helping Spain to become world football's dominant team with a first World Cup triumph sandwiched between consecutive European championship titles.
The pair, whose candidacy was put forward by FIFA president Sepp Blatter, edged the International Paralympic Committee to win an annual prize of 50,000 euros ($61,827) awarded since 1981.
They were also 2010 winners when Spain was honoured.
Blatter says they 'are an example to follow, representing Spanish unity above the differences of the Real Madrid-Barcelona rivalry'.