The former Barcelona player spent the latter half of last season on loan at AC Milan, scoring twice in 11 appearances.
At 28, he has become something of a journeyman, with Sampdoria set to be his eighth professional club and the fourth he has joined on loan.
"Catania announces that it has reached an agreement with Sampdoria, to be formalised after a medical scheduled tomorrow in
Sampdoria also confirmed the deal with a short statement on its own website.
Lopez began his career with
He initially impressed, scoring 12 league goals in 17 appearances in the half-season after joining Catania in
Sampdoria completed a double over Serie A champion Juventus with a 3-2 win at a rainswept Stadio Luigi Ferraris - to end the season in 14th place.