Wolverhampton will be without wingers Razak Boukari and Stephen Hunt against Crystal Palace at Molineux as it looks to make it five successive Championship wins.
New signing Boukari will be out for up to six weeks with a calf injury sustained in Saturday's 1-0 win against Sheffield Wednesday.
Hunt is set for a more lengthy spell on the sidelines as he prepares for surgery on a troublesome hip problem.
"We got a bad injury on Saturday with Razak," Wolverhampton manager Stale Solbakken told the club's official website, www.wolves.co.uk.
"Hopefully it will be three weeks and not six but we don't know. He has to have a scan and then we'll know.
"Hunty has had this problem for a long time where it feels loose around his hip and he needs to have this addressed because he's 31, not 41 and he has a few years left playing in him.
"I think we saw how he was affected in the Chelsea [League Cup] game and he will need to have an operation.
"He doesn't feel 100 per cent and I think he has to do something about it now.
"He has tried to play through the pain barrier for quite a few weeks and wanted to impress me but has not been able to do himself justice."
The club is also monitoring centre-back Georg Margreitter's hip complaint, while Solbakken backed left-back George Elokobi after he broke and dislocated his ankle in his first loan game at Bristol City.
"George was very unlucky to get such a serious injury in his first loan game," the Norwegian added. "But knowing him he will fight very hard to get back."
Wolverhampton is one of three sides flying high on 16 points after the opening eight matches of the campaign.
Bottom side Peterborough will be looking to build on its first win of the season when it travels to
Its fellow struggler Millwall heads to Bristol City, while Sheffield Wednesday will be looking to end its poor recent run at Burnley.
Charlton welcomes Watford to the Valley, while Huddersfield takes on Leicester, Hull faces Blackpool and Bolton hosts Leeds.
Pedj Bojic knows what it takes to win an A-League championship and he believes his new club Sydney FC look the goods for next season.