Advantage to Manchester United

Having surprisingly dropped out of the UEFA Champions League, Sir Alex Ferguson's side was handed a tricky last-32 pairing with the Dutch side, but claimed the first leg with little drama.

The host side had the better of a goalless first-half but United took control after the break, with Ashley Young opening the scoring after 59 minutes and Javier Hernandez adding the second five minutes from time.

Atletico Madrid also impressed, seeing off Lazio 3-1 at the Stadio Olimpico.

Germany striker Miroslav Klose gave the Serie A side the lead in the 19th minute but the Spanish side came back hard with three away goals that puts the tie firmly in its favour.

Adrian equalised six minutes after the opener, with Falcao (37, 63) scoring either side of the interval.

Salzburg is all but out of the competition after a 4-0 drubbing by visiting Metalist Kharkiv.

Metalist scored in the first and last minutes of the match through Taison and Bonfim Marlos, with Jonathan Cristaldo scoring a twice in three minutes in between.

Lokomotiv Moscow took the win but surrendered an away goal in a 2-1 success of Athletic Bilbao.

Iker Munain put the Primera Division side in front but second-half strikes from Felipe Caceido and Denis Glushakov (penalty), reversed the result.

Schalke drew 1-1 at Viktoria Plzen, Klaas Jan-Huntelaar equalising Vladimar Darida's first-half effort.

Legia Warsaw and Sporting also drew 2-2 in Poland, with the Portuguese side equalising twice through Daniel Carrico and Andre Santos after goals from Jakub Wawrznyiak and Janusz Gol.

In the Netherlands, AZ Alkmaar edged Anderlecht 1-0 courtesy of Adam Maher's 35th-minute shot.