Matchwinner ... Kozak (left) celebrates his goal for Lazio (Getty)
The host side trailed 2-0 at half-time and was a man down after Abdoulay Konko was sent off in the 33rd minute, but goals from Hernanes, Senad Lulic and substitute Libor Kozak denied Cesena its first ever league win in Rome.
Cesena had gone in front in the 14th minute through Adrian Mutu, who then earned a penalty after being fouled by Konko, who was shown a straight red.
Vincenzo Iaquinta, making his debut with Cesena after joining the club on loan from Juventus last month, converted the penalty to put his team 2-0 up after 33 minutes.
Lazio then struck three times to claim maximum points and lift it above Udinese and into third place.
Udinese, which is one point behind the Roman side, hosts AC Milan on Saturday (Sunday AEDT).
The defeat left Cesena in 19th place, four points off safety.
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