Serie A new boy Pescara was given a less-than-friendly introduction to life in the top flight as it was beaten 3-0 by Inter Milan.
Pescara, second-tier champion last season, was always going to be up against it at the Stadio Adriatico and so it proved as
Sampdoria made a winning return to Serie A with a shock 1-0 victory at AC Milan.
Lazio also opened its campaign with a 1-0 victory at Atalanta, courtesy of Anderson Hernanes' 18th-minute goal.
Napoli's bid to improve on last term's top-five finish got off to a flying start with a 3-0 victory in Palermo.
Chievo kicked off the new season with a workmanlike 2-0 victory over Bologna.
Second-half goals from
Siena, which is trying to overturn a six-point deduction for its part in a match-fixing scandal, could only manage a goalless draw against newly-promoted Torino.
AC Milan produced a dramatic late fightback to win 2-1 at Siena and book its place in next season's UEFA Champions League at the expense of Fiorentina.