Champion Borussia Dortmund will be bidding to get its campaign back on track after its weekend loss when it travels to unbeaten Eintracht Frankfurt in the Bundesliga on Tuesday.
Dortmund saw its 31-match unbeaten run ended with a 3-2 reverse at Hamburg on Saturday and, with seven points from four games, it needs a win to keep in touch with leaders Bayern Munich and promoted Eintracht, both of which have a maximum 12 points.
Leader Bayern hosts Wolfsburg at its Allianz Arena stadium on Tuesday.
Dortmund coach Juergen Klopp says he has no concerns about his team being in fourth place, pointing out that he had "never coached a team who were on top after five days" and warning that his troops would show "all their potential during the season".
Last season, Dortmund was 11th after five matches before going on to mount a successful title defence, but rival Eintracht is not to be taken lightly, having scored 11 goals in four games and conceded just four.
Eintracht has a doubt surrounding the presence of captain Pirmin Schwegler, who has been given a "50/50 chance" of recovering in time by coach Armin Veh after suffering a head knock in Friday's 2-1 win at Nuremberg, while Canadian striker Olivier Occean will miss the game with a hip injury.
Bayern, meanwhile, is top of the goalscoring chart with 14 scored and just two conceded, but goalkeeper Manuel Neuer warned against premature celebrations.
"We must not be lulled but continue our daily work to maintain the same level," he said.
The Germany international is one of the few members of the Bayern squad assured of his place in the team, with the club having signed several players and coach Jupp Heynckes determined to rotate against Wolfsburg, which is coached by former Bayern boss Felix Magath.
"Everyone must put their ego aside and accept spending some time on the bench," said Heynckes after his side's 2-0 win over Schalke.
Competition for places is particularly tight in midfield, where there are nine candidates for five places.
In-form Toni Kroos and Thomas Mueller could have to step aside for Arjen Robben or Franck Ribery, who has recovered from a thigh injury, while Heynckes could opt to give Spanish star Javi Martinez his first Bundesliga start.
Schalke, in fifth, will be looking to put its loss to Bayern behind it when it hosts Mainz before going to Fortuna Duesseldorf on Saturday, with a Champions League home tie against Montpellier looming on Wednesday.
However, Klaas-Jan Huntelaar (toe) and Ibrahim Afellay (cold) are doubts for the game, as is Jermaine Jones (ankle).
Elsewhere, ninth-placed Borussia Moenchengladbach hosts Hamburg, while third-placed Hannover takes on Nuremberg, with Mirko Slomka's side looking to bounce back from its first loss of the season at the hands of Hoffenheim on Sunday.
Eintracht Frankfurt goalkeeper Oka Nikolov will end a 19-year association with the Bundesliga club to continue his career in Major League Soccer.