Schalke 04 is hoping to come out on top against Bayern Munich this weekend, buoyed by victory in its UEFA Champions League opener against Olympiakos.
The Gelsenkirchen club beat the Greek side 2-1 but goes into the match knowing it failed to take a point from Bayern last season and also came away empty-handed from ties with eventual champion Borussia Dortmund.
Manager Horst Heldt said finding weaknesses in the Bayern line-up was always tough but unlike in the last campaign, when his side lost 2-0 twice, it needed to be decisive against the current league leader.
"We were disappointed with how we played in the big games last season, with the exception of the home game against Dortmund (which they lost 2-1)," said Heldt.
"But in Dortmund and twice against Bayern we didn't have any courage. You can't win anything like that. Of course it's important to see to it that the team plays in a different manner.
"After all we're playing against one of the favourites for the championship."
Schalke goes into the game with a doubt over midfielder Jermaine Jones, who suffered an ankle injury in the victory over Olympiakos, while Bayern coach Jupp Heynckes is expected to continue rotating his players, with strength in depth.
"We have some very good options personnel-wise," said Heynckes, whose side was 2-1 winners at home against Valencia in the Champions League midweek.
"I will not explain to my players why and how I am making changes. They must accept it."
Like fourth-placed Schalke, Dortmund has seven points. It is playing on Saturday (Sunday AEST) at struggling Hamburg, which is second-last in the table after three defeats in three matches.
Dortmund needed a late goal by Robert Lewandowski to grab a 1-0 win at home over Ajax Amsterdam to kick off its Champions League campaign.
And coach Jurgen Klopp will now analyse how the midfield duo of Mario Gotze and Marco Reus performed and if he wants to line them up together in Hamburg.
"We will have a lot of work before it works perfectly," admitted Reus.
Hamburg coach Thorsten Fink meanwhile said the Bundesliga champion was coming at exactly the perfect time.
"We are the underdogs on Saturday (Sunday AEST) and we can only surprise in a positive manner," said Fink.
"If I am given the time, we will move up the table."
The last time Hamburg had zero points after three matches was way back in September 1972. But the club's management still has faith in Fink.
"We are totally convinced of his work. He will get his time," said club chairman Carl-Edgar Jarchow.
Friday's (Saturday AEST) match sees Nuremberg play Eintracht Frankfurt, with the newly-promoted side's coach Armin Veh, who guided VfB Stuttgart to the 2007 Bundesliga crown, upbeat after three straight wins in the opening games.
"I would be disappointed now if we don't win the championship," Veh joked in an interview with Kicker magazine.
"That doesn't mean I don't take my work extremely seriously. But still I need a certain looseness."
Veh will have his sights set on stopping Nuremberg's Japanese star Hiroshi Kiyotake.
The midfielder has delivered three assists and a goal in his last two matches and helped Nuremberg to seven points.
The other Saturday (Sunday AEST) games see VfL Wolfsburg host Greuther Fuerth; Augsburg plays at Mainz 05 in a battle of teams with just one point; and Freiburg heading to Fortuna Dusseldorf, the only team not to have conceded a goal this season.
On Sunday (Monday AEST), Bayer Leverkusen host Borussia Monchengladbach; Werder Bremen welcomes VfB Stuttgart and Hanover 96 travels to last place Hoffenheim.
Hoffenheim claimed a vital 3-1 win against second-tier Kaiserslautern in the first leg of the Bundesliga play-off.