Bayern Munich is set to defend its Bundesliga lead at home against Mainz with coach Jupp Heynckes having a luxury problem.
Heynckes needs to decide whether to give record signing Javi Martinez a starting place on Saturday against a team struggling on one point.
The coach has said his first impression of the Spanish international had been confirmed.
"He'll be a huge bonus for us in footballing terms. He gives us even more quality in midfield, which is a motivating factor for everyone.
"But even Javi will have to play and fight his way into the team based on his performance. Obviously he has my full support, just like all the other players."
The only other team in the league with a maximum six points, Eintracht Frankfurt, is also at home as it faces SV Hamburg in one of two matches on Sunday.
Hamburg lost its two opening matches and is under tremendous pressure.
Rafael van der Vaart, who joined the club from northern Germany on the last day of the transfer window, is expected to start as coach Thorsten Fink tries to turn things around.
Defending champion Borussia Dortmund, which is chasing a hat-trick of titles, takes on Bayer Leverkusen.
There was good news for Dortmund coach Juergen Klopp as the injury that forced Footballer of the Year Marco Reus off the field at half-time in Germany's midweek 2-1 victory in Austria is not so serious as to put his playing against Leverkusen in jeopardy.
Bundesliga rookie Greuther Fuerth, which lost its opening game at home to Bayern Munich but then bounced back to win in Mainz, faces Champions League participant Schalke 04.
Ibrahim Afellay, who signed for Schalke from Barcelona, scored three goals in a friendly and is expected to play his first league match on Saturday, said the friendly gave him confidence for the tasks ahead.
"The match was great fun. And to get on the scoresheet straightaway was brilliant, of course," the midfielder said.
Fans of VfB Stuttgart, which is sitting bottom of the table, is hoping the team will pick up its first points at home against newly promoted Fortuna Dusseldorf.
Last season's surprise team Borussia Moenchengladbach, is home to Nuremberg, while Augsburg faces Wolfsburg at home on Friday.
Augsburg, which last season surprisingly avoided relegation, has lost both opening matches, while Wolfsburg managed to win in Stuttgart but was thrashed 4-0 at home by Hanover in its next match.
Wolfsburg coach Felix Magath said he expected his players to bounce back. "I can't imagine that the team will not show a reaction on Friday."
The other games pits Hanover against Werder Bremen and SC Freiburg against Hoffenheim.
Hoffenheim claimed a vital 3-1 win against second-tier Kaiserslautern in the first leg of the Bundesliga play-off.