"It's always a problem when you lose players like him. We know how important Puyol is to the team. He played well throughout the match, he brings a lot to the team. Hopefully we can get him back soon," Barca coach
Puyol missed EURO 2012 due to injury, and has only just recovered from a broken cheekbone, playing against Getafe with a custom-made face mask.
Puyol is Barca's fourth big name injury victim, along with Andres Iniesta, Alexis Sanchez and Jordi Alba.
Barca, whose victory over Getafe was its fourth in four league matches this season, begins its UEFA Champions League campaign against Spartak Moscow midweek.
Neymar appears to be moving closer to joining Barcelona after his club Santos announced it had accepted two bids for the Brazil forward.